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Manimekalai, P.
- A Preclinical Evaluation on Antioxidant and Gastroprotective Effect of Dioscorea Bulbifera in Wistar Rats
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Authors
Affiliations
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 3 (2012), Pagination: 149-154Abstract
The present study was undertaken to evaluate the gastro-protective effect of hydro alcohol extract of Dioscorea bulbifera (DB) tubers Linn in indomethacin-induced gastric ulcers in rats at doses of 100, 200 and 400 mg/kg body weight. The gastric lesions were significantly reduced by all doses of DB as compared with the Indomethacin (100 mg/kg body weight) treated group. In the stomach tissues of treated animals, the in-vitro antioxidant levels were evaluated. The administration of indomethacin caused a significant decrease in the levels of peroxidase, catalase (CAT) and an increase in glutathione peroxidase (GPx) and reduced glutathione (GSH), and lipid peroxidation (LPO) level. The administration of all doses of DB reversed the trend, inducing a significant increase of peroxidase, Catalase and a reduction in GPx, GSH and LPO level in tissues. These results suggest that the gastro-protective effect of DB can be attributed to its reducing effect on the oxidative damage in rats.Keywords
Gastro-protective Activity, Dioscorea Bulbifera, Indomethacin, Antioxidant ActivityReferences
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- Anti-Antioxidant Activity of Alcoholic Extract of Nelumbo nucifera on Streptozotozin Induced Diabetic Albino Wistar Rats
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PDF Views:492
Authors
Affiliations
1 Sughavazhvu Health Care, Thanjavur-613007, TN, IN
2 Center for advanced research in Indian system of medicine, Sastra University, Thanjavur-614904. TN, IN
1 Sughavazhvu Health Care, Thanjavur-613007, TN, IN
2 Center for advanced research in Indian system of medicine, Sastra University, Thanjavur-614904. TN, IN
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 3 (2012), Pagination: 70-77Abstract
The present study is to evaluate the in-vivo anti oxidant effect of hydro alcohol (50% aqueous ethanolic extract) extract of Nelumbo nucifera (G) flowers on streptozotocin-induced diabetes. Animals were induced for diabetes with streptozotocin (60 mg/kg of body weight, i.p.) and treated orally with hydro- alcoholic (50% aqueous ethanolic extract) extract of Nelumbo nucifera (G.) flowers in various doses (200 mg/kg and 400 mg/kg p.o). The effect of Nelumbo nucifera (G) flowers on diabetes was assessed from plasma glucose. At the end of the study, vital organs were dissected and estimated the parameters such as LPO, GSH, GPx and peroxidase. From the data obtained in this study it could be concluded that hydro alcoholic extract of Nelumbo nucifera (G) flowers seems to have potential value for the treatment of diabetic due to its Anti oxidant activity.Keywords
Anti Diabetic, Anti-oxidants,Nelumbo NuciferaReferences
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- Evaluation of In vivo Wound Healing Activity of dried leaf Ethanolic extract of Indigofera tinctoria on Albino Wistar Rat
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Authors
Affiliations
1 Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal (DT), IN
2 Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam-600117, IN
1 Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal (DT), IN
2 Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam-600117, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 827-830Abstract
Aim of the present study was to evaluate the wound healing properties of ethanolic extract of Indigofera tinctoria on Albino wistar rat. The preliminary Phytochemical evaluation was carried out by standard methods. Burn was induced in wistar rat divided in to five groups as follow: Normal control Group-I received petroleum jelly. Group II Received Silver sulphadiazine-1%w/w,Group III received 5% extract of Indigofera tinctoria ointment, Group IV received 10% w/w Indigofera tinctoria ointment and GroupV received 20% w/w Indigofera tinctoria ointment topically twice daily for 16 days. The topical application of 20% w/w Indigofera tinctoria ointment, shows significant (P<0.001) reduction in the wound breaking strength when compared to III received 5% extract of Indigofera tinctoria ointment but not comparable with Silver sulphadiazine-1%w/w treated group.Keywords
Wound Healing Activity, Indigofera tinctoria, Hydroxyproline, Epithelialization.References
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